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Nucleosides and Nucleotides Volume 17, 1998 - Issue 1-3
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Original Articles

Effect of Cu2+ on Complex Formation Between a Deoxyribozyme and Its SubstratesFootnote†

Naoki Sugimoto Department of Chemistry, Faculty of Science, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe, 658, Japan
&
Noboru Wakizaka Department of Chemistry, Faculty of Science, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe, 658, Japan
Pages 565-574 | Published online: 22 Aug 2006
 
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Abstract

Effect of metal ions on secondary-structure formation of a deoxyribozyme-two substrates complex has been investigated by using surface plasmon resonance and secondary-structure predicting calculation. The result showed that Cu2+ not only acts on the ligation reaction but also plays the role of a promoter which makes an active conformation of the deoxyribozyme-substrate complex.

This paper is dedicated to the late Professor Tsujiaki Hata.

Notes

This paper is dedicated to the late Professor Tsujiaki Hata.

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