Characterization of Telomeric Oligonucleotides: Fidelity of Repetitive Nucleotide SequencesFootnote§
This paper is dedicated in memory of Prof. Tsujiaki Hata.

Toshio Shida Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano, 386, Japan

Mitsuaki Suda Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano, 386, Japan

Junichi Sekiguchi Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano, 386, Japan

Abstract

To clarify the reasons for the high fidelity of repetitive telomeric sequences, a series of d(TTXGGG)₄ (X: A, G, C, and T) were synthesized and characterized by UV absorption, CD, chemical modification, and resistance to nucleases. d(TTCGGG)₄, which is lacking in nature, has similar structural stability and resistance to nucleases, compared with d(TTAGGG)₄, which is widely present at the telomeres of many organisms. d(TTGGGG)₄ is the most stable as a result of formation of the four G-quartet layers in the presence of potassium ion.

This paper is dedicated in memory of Prof. Tsujiaki Hata.

Notes

This paper is dedicated in memory of Prof. Tsujiaki Hata.

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Characterization of Telomeric Oligonucleotides: Fidelity of Repetitive Nucleotide SequencesFootnote§
This paper is dedicated in memory of Prof. Tsujiaki Hata.

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Characterization of Telomeric Oligonucleotides: Fidelity of Repetitive Nucleotide SequencesFootnote§This paper is dedicated in memory of Prof. Tsujiaki Hata.

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Characterization of Telomeric Oligonucleotides: Fidelity of Repetitive Nucleotide SequencesFootnote§
This paper is dedicated in memory of Prof. Tsujiaki Hata.