Stabilization of Deoxyadenosine/polynucleotide Complexes by 3′,5′-Di-O-Benzoyl SubstituentsFootnote#
This paper is dedicated in memory of Professor Tsujiaki Hata - a premier scientist, a creative leader in the field of nucleic acid chemistry, and a warm friend.

S. K. Chaturvedi Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA

R. L. Letsinger Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA

Abstract

3′,5′-Di-O-benzoyldeoxyadenosine forms stable dT:dA:dT type complexes with poly(dT) and an oligo(dT)-cholesteryl conjugate in dilute aqueous solution. The benzoyl groups play an essential role in stabilizing these “triple stranded” complexes.

This paper is dedicated in memory of Professor Tsujiaki Hata - a premier scientist, a creative leader in the field of nucleic acid chemistry, and a warm friend.

Notes

This paper is dedicated in memory of Professor Tsujiaki Hata - a premier scientist, a creative leader in the field of nucleic acid chemistry, and a warm friend.

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Stabilization of Deoxyadenosine/polynucleotide Complexes by 3′,5′-Di-O-Benzoyl SubstituentsFootnote#
This paper is dedicated in memory of Professor Tsujiaki Hata - a premier scientist, a creative leader in the field of nucleic acid chemistry, and a warm friend.

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Stabilization of Deoxyadenosine/polynucleotide Complexes by 3′,5′-Di-O-Benzoyl SubstituentsFootnote#This paper is dedicated in memory of Professor Tsujiaki Hata - a premier scientist, a creative leader in the field of nucleic acid chemistry, and a warm friend.

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Stabilization of Deoxyadenosine/polynucleotide Complexes by 3′,5′-Di-O-Benzoyl SubstituentsFootnote#
This paper is dedicated in memory of Professor Tsujiaki Hata - a premier scientist, a creative leader in the field of nucleic acid chemistry, and a warm friend.