d(GCGTAGC), an Equilibrium Between a Hairpin Structure and an Unusual Duplex

Evline Lescrinier Laboratory of Medicinal Chemistry, Rega Institute for Medical Research and Faculty of Pharmacy, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium

Shqun Sheng Department of Chemistry, Georgia State University, University Plaza, Atlanta, GA, 30303-3083, USA

Ja Schraml Institute of Chemical Process Fundamentals, Rozvojova 135, 165 02, Prague 6, Czech Republic

Roger Busson Laboratory of Medicinal Chemistry, Rega Institute for Medical Research and Faculty of Pharmacy, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium

Piet Herdewijn Laboratory of Medicinal Chemistry, Rega Institute for Medical Research and Faculty of Pharmacy, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium

Abstract

The DNA heptamer d(GCGTAGC), as determined by NMR spectroscopy, occurs in aqueous solution in a temperature-and salt-dependent equilibrium between a monoloop hairpin (where the unpaired thymidine, forming the loop, is stacked on top of the guanine (G3) base) and a duplex with the unpaired thymidine residues from opposite strands intercalating and costacking between shared G:A pairs.

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d(GCGTAGC), an Equilibrium Between a Hairpin Structure and an Unusual Duplex

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d(GCGTAGC), an Equilibrium Between a Hairpin Structure and an Unusual Duplex

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