Stereoselective Synthesis of β-L-2′, 3′-Dideoxy-and L-2′,3′-Didehydro-2′,3′-Dideoxy Purine Nucleosides

Peiyuan Wang Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, Athens, Georgia, 30602

Pascal J. Bolon Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, Athens, Georgia, 30602

M. Gary Newton Department of Chemistry, The University of Georgia, Athens, Georgia, 30602

Chung K. Chua Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, Athens, Georgia, 30602

Abstract

β-L-2′, 3′-Dideoxy- and L-2′, 3′-didehydro-2′, 3′-dideoxy purine nucleosides have been synthesized via a highly stereoselective method of glycosylation by the condensation of L-2-(phenylseienyl)-2, 3-dideoxyribose derivative with silylated heterocyclic base.

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Stereoselective Synthesis of β-L-2′, 3′-Dideoxy-and L-2′,3′-Didehydro-2′,3′-Dideoxy Purine Nucleosides

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Stereoselective Synthesis of β-L-2′, 3′-Dideoxy-and L-2′,3′-Didehydro-2′,3′-Dideoxy Purine Nucleosides

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