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ORIGINAL ARTICLEClinical Translational Therapeutics

Urticaria and Angioedema in Renal Cell Cancer Patients Treated with IL-2

, M.D., , M.D. & , M.D.
Pages 584-588 | Published online: 11 Jun 2009
 

Abstract

Interleukin-2 therapy has produced significant improvement in a proportion of patients with renal cell cancer. Dermatologic side effects, such as erythema, have been very common. However, we could find only 2 reports of urticaria in the medical literature.

Here, we report 8 patients with renal cell cancer who developed urticaria in association with interleukin-2 therapy. The hives tended to occur at the end of a treatment cycle. Skin tests with IL-2 were negative in two patients. Urticaria did not worsen or consistently occur with repeated courses of interleukin-2 and anaphylaxis was not observed in any patient. Six of the 8 patients previously had urticaria unrelated to IL-2 therapy.

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