Circulating Stromal Cell Derived Factor-1α (SDF-1α) is Predictive of Distant Metastasis in Gastric Carcinoma

In Sook Woo Division of Medical Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea

Sook Hee Hong Division of Medical Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea

Jae Ho Byun Division of Medical Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea

Jin-Hyung Kang Division of Medical Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea

Hae-Myung Jeon Department of Surgery, College of Medicine, Catholic University, Seoul, Korea

Myung Gyu Choi Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea

Abstract

This study was conducted to investigate the value of the pretreatment circulating stromal cell derived factor-1α(SDF-1α) in patients with gastric carcinoma. We measured SDF-1α serum concentrations and evaluated the relationship between serum SDF-1α and serum vascular endothelial growth factor (VEGF) levels and clinical factors in 107 gastric cancer patients. Serum levels of SDF-1α and VEGF levels were higher in gastric cancer patients than in controls (p < 0.001). Serum SDF-1α levels were higher in metastatic patients than non-metastatic patients (p < 0.001). SDF-1α levels were correlated with the presence of distant metastases (r = 0.528; p < 0.001) and correlated with VEGF levels (r = 0.789; p < 0.001). SDF-1α might serve as a possible marker for predicting or monitoring distant metastasis in gastric carcinoma.

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Circulating Stromal Cell Derived Factor-1α (SDF-1α) is Predictive of Distant Metastasis in Gastric Carcinoma

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Circulating Stromal Cell Derived Factor-1α (SDF-1α) is Predictive of Distant Metastasis in Gastric Carcinoma

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