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Abstract
A transgenic mouse model of autochthonous mammary carcinoma was chosen to study the impact of tumor progression on the immune system over an extended period. We found: i) that splenocyte numbers, particularly myeloid cells, increased concurrently with tumor burden; ii) the percentage of tumor-infiltrating Treg cells was similar to that in human breast cancer; iii) suppressed T cell proliferation and cytokine production and; iv) significantly elevated MCP-1 and TNF-α in the sera of tumor-bearing mice. The modified immune status in these tumor-bearing hosts is consistent with a “syndrome” that likely impacts the efficacy of cancer immunosurveillance and response to therapy.
| ABBREVIATIONS | ||
| Ag | = | antigen |
| CTL | = | cytotoxic T lymphocyte |
| ConA | = | Concanavalin A |
| LN | = | Lymph node |
| LNC | = | Lymph node cell |
| LPS | = | Lipopolysaccharide |
| MCP-1 | = | monocyte-chemoattractant protein-1 |
| MDSC | = | myeloid derived suppressor cell |
| MTAG | = | Middle T AntiGen |
| NKT | = | natural killer T |
| TCR | = | T cell receptor |
| TDLNs | = | Tumor-draining lymph nodes |
| Tg+ | = | transgene positive |
| Tg− | = | transgene negative |
| TNF-α | = | tumor-necrosis factor-α |
| Treg | = | regulatory T cell |
| ABBREVIATIONS | ||
| Ag | = | antigen |
| CTL | = | cytotoxic T lymphocyte |
| ConA | = | Concanavalin A |
| LN | = | Lymph node |
| LNC | = | Lymph node cell |
| LPS | = | Lipopolysaccharide |
| MCP-1 | = | monocyte-chemoattractant protein-1 |
| MDSC | = | myeloid derived suppressor cell |
| MTAG | = | Middle T AntiGen |
| NKT | = | natural killer T |
| TCR | = | T cell receptor |
| TDLNs | = | Tumor-draining lymph nodes |
| Tg+ | = | transgene positive |
| Tg− | = | transgene negative |
| TNF-α | = | tumor-necrosis factor-α |
| Treg | = | regulatory T cell |