FKBP51 Expressed by Both Normal Epithelial Cells and Adenocarcinoma of Colon Suppresses Proliferation of Colorectal Adenocarcinoma

Hiromi Mukaide First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan

Yasushi Adachi First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan; Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan

Shigeru Taketani Department of Biotechnology, Kyoto Institute of Technology, Sakyo-ku, Kyoto, Japan

Masayoshi Iwasaki First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan

Naoko Koike-Kiriyama First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan

Akio Shigematsu First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan

Ming Shi First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan

Seiji Yanai First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan

Kazuhiko Yoshioka Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan

Yasuo Kamiyama Department of Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan; Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan

Susumu Ikehara First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan; Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan; Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan

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Abstract

It has been reported, as a result of Western blot analyses, that FKBP51 is expressed in various tissues, but that it is not expressed in the pancreas, lung, colon, stomach, or spleen. In this paper, we show, using Western blot analyses, reverse transcriptase polymerase chain reaction, and immunohistochemical analyses of samples from colon cancer patients, that both normal epithelial cells and adenocarcinoma in the human colon express FKBP51, and that there are no significant differences in the expressions of FKBP51 between them. We also show that FKBP51 suppresses the proliferation of colorectal adenocarcinoma, possibly due to the suppression of functions of the glucocorticoid receptors.

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FKBP51 Expressed by Both Normal Epithelial Cells and Adenocarcinoma of Colon Suppresses Proliferation of Colorectal Adenocarcinoma

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FKBP51 Expressed by Both Normal Epithelial Cells and Adenocarcinoma of Colon Suppresses Proliferation of Colorectal Adenocarcinoma

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