Prostate Tumor-Inducing Gene-1 Analysis in Human Prostate Cancer Cells and Tissue in Relation to Mycoplasma Infection

Abstract

The potential role of PTI-1, in the natural story of prostate adenocarcinoma remains to be fully determined. PTI-1 expression was evaluated in human prostate cancer cell lines and in paraffin-embedded archive tissues. PTI-1 expression was found in Mycoplasma infected but not in non-infected cells. The lack of PTI-1 expression was also confirmed in fixed and paraffin-embedded human cancer prostate biopsies. The overall data indicate that, in prostate tumor cell lines, PTI-1 presence parallels Mycoplasma infection suggesting that PTI-1 might not necessarily play a major role in the onset of prostate tumorigenesis.

Keywords:

• PTI-1
• Human prostate cancer cell lines
• Paraffin-embedded tissue
• Mycoplasma
• RT-PCR