Can The Lack of HSP90α Protein in Brain Normal Tissue and Cell Lines, Rationalise it as a Possible Therapeutic Target for Gliomas?

Amal Shervington Neurosurgery Department, Royal Preston Hospital, Brain Tumor North West, Preston, UK

Nichola Cruickshanks Neurosurgery Department, Royal Preston Hospital, Brain Tumor North West, Preston, UK

Robert Lea Faculty of Science and Technology, University of Central Lancashire, Preston, UK

Gareth Roberts Faculty of Science and Technology, University of Central Lancashire, Preston, UK

Tim Dawson Pathology Laboratory, Royal Preston Hospital, Preston, UK

Leroy Shervington Neurosurgery Department, Royal Preston Hospital, Brain Tumor North West, Preston, UK

Abstract

Despite studies suggesting a role for HSP90α in tumorigenesis, there are no reports as to its expression in normal human brain tissue. In this study, the expression of HSP90α was evaluated in both cell lines (3 gliomas and 2 controls) and brain tissue specimens of 10 patients (8 gliomas and 2 normal brain tissues). No HSP90α protein was detected in either normal cell lines or normal brain tissue. However, 8/8 glioma tissues and 3/3 glioma cell lines did express HSP90α. These findings provide a rationale for targeting HSP90α protein as a therapeutic candidate for glioma.

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Can The Lack of HSP90α Protein in Brain Normal Tissue and Cell Lines, Rationalise it as a Possible Therapeutic Target for Gliomas?

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Can The Lack of HSP90α Protein in Brain Normal Tissue and Cell Lines, Rationalise it as a Possible Therapeutic Target for Gliomas?

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