Expression of Decorin in Esophageal Cancer in Relation to the Expression of Three Isoforms of Transforming Growth Factor-Beta (TGF-β1, -β2, and -β3) and Matrix Metalloproteinase-2 Activity

K. Augoff Department of Gastrointestinal and General Surgery, University of Wroclaw, Poland

K. Grabowski Department of Gastrointestinal and General Surgery, University of Wroclaw, Poland

J. Rabczynski Department of Pathological Anatomy, Wroclaw Medical University, University of Wroclaw, Poland

A. Kolondra Institute of Biochemistry and Molecular Biology, University of Wroclaw, Poland

R. Tabola Department of Gastrointestinal and General Surgery, University of Wroclaw, Poland

A. F. Sikorski Institute of Biochemistry and Molecular Biology, University of Wroclaw, Poland

Abstract

To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-β expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the pathological tissues. No obvious alterations in TGF-β expression were noticed. The highly significant increase in MMP-2 activity in cancers did not result in elevated levels of TGF-β dimers. Therefore, the system of TGF-β liberation from its complex with DCN by activated MMP-2 does not seem to contribute to esophageal cancerogenesis, although this hypothesis should be reevaluated with a larger study group.

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Expression of Decorin in Esophageal Cancer in Relation to the Expression of Three Isoforms of Transforming Growth Factor-Beta (TGF-β1, -β2, and -β3) and Matrix Metalloproteinase-2 Activity

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Expression of Decorin in Esophageal Cancer in Relation to the Expression of Three Isoforms of Transforming Growth Factor-Beta (TGF-β1, -β2, and -β3) and Matrix Metalloproteinase-2 Activity

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