A First Report of Radioembolization for Hepatic Metastases From Ocular Melanoma

Abstract

Background: Ocular melanoma (OM) metastasizes to the liver and is rapidly fatal despite aggressive therapy. Yttrium-90 microspheres (radioembolization) delivered via the hepatic artery is an established and effective approach for primary and metastatic hepatic tumors, although ⁹⁰Y use in OM has not been reported previously. Methods: A retrospective review was performed for all patients with OM who received radioembolization at 5 centers. Results: 11 patients received 12 treatments with a median activity of 1.55 GBq delivered per treatment. Toxicity was minimal, with PET/CT at 3 months posttreatment showing a response in all patients; 1 patient had a complete response. Conclusions: Radioembolization can control hepatic metastases of OM with very few side effects.

Keywords:

• Yttrium-90
• Microsphere
• Liver
• Choroidal
• Melanoma
• Metastases
• Uveal
• Hepatic
• Brachytherapy