Specific Reduction of Fas-Associated Protein with Death Domain (FADD) in Clear Cell Renal Cell Carcinoma

Hui Xu Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China

Lizhi He The Hamilton Centre for Kidney Research (HCKR), Division of Nephrology, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Departments of Medicine, McMaster University, Hamilton, Ontario, Canada

Xinchang Feng The Hamilton Centre for Kidney Research (HCKR), Division of Nephrology, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Departments of Medicine, McMaster University, Hamilton, Ontario, Canada

Anil Kapoor The Hamilton Centre for Kidney Research (HCKR), Division of Nephrology, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Departments of Surgery, McMaster University, Hamilton, Ontario, Canada

Damu Tang The Hamilton Centre for Kidney Research (HCKR), Division of Nephrology, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Departments of Medicine, McMaster University, Hamilton, Ontario, Canada

Abstract

Fas-associated protein with death domain (FADD) plays a major role in the execution of apoptosis. Attenuation of apoptosis is a hallmark of cancer. Through systemic examination of FADD in renal cell carcinoma (RCC) and adjacent nontumor kidney tissues from 85 patients, we demonstrated a significant reduction of FADD in clear cell RCC (ccRCC) compared to the respective nontumor kidney tissues. In human kidney, FADD is expressed in both the proximal and distal tubules. As ccRCC originates from the proximal tubular epithelium, reduction of FADD in ccRCC indicates that FADD-mediated apoptosis may inhibit ccRCC tumorigenesis.

Keywords:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Specific Reduction of Fas-Associated Protein with Death Domain (FADD) in Clear Cell Renal Cell Carcinoma

Information for

Open access

Opportunities

Help and information

Specific Reduction of Fas-Associated Protein with Death Domain (FADD) in Clear Cell Renal Cell Carcinoma

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature