Prognostic Value of the t(14;18)(q32;q21) in Patients With Diffuse Large B-Cell Lymphoma

Hasan Abdel-GhaffarMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Sherin Abd El-AzizMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Doaa ShahinMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Heba DegheidyMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Tarek SelimMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Ezzat ElsobkyMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Nadia AttwanMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Youssef A. Al-TonbaryMansoura University, Mansoura, Egypt, Department of Genetics, AinShams University, Cairo, Egypt, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

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ABSTRACT

The prognostic significance of the t(14;18) in diffuse large B-cell lymphoma is still controversial. To assess the impact of the t(14;18) on patient survival, we investigated 26 patients with diffuse large B-cell lymphoma for the presence of t(14;18). The t(14;18) was detected in 90.9% of patients with high international prognostic index score. The five-year overall survival was 0.0% and 68.75% in positive and negative cases of t(14;18) respectively. The detection of the t(14;18) combined with the international prognostic index score is a useful strategy for more appropriate risk stratification and prediction of outcome of patients with diffuse large B-cell lymphoma.

Keywords: :

ACKNOWLEDGMENT

The authors thank Dr. Nadia Mokhtar, the head of the pathology department in the National Cancer Institute, for her kind care and her technicians workgroup.

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Prognostic Value of the t(14;18)(q32;q21) in Patients With Diffuse Large B-Cell Lymphoma

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Prognostic Value of the t(14;18)(q32;q21) in Patients With Diffuse Large B-Cell Lymphoma

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