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Brief Report

Tumor Inhibition by Enzalutamide in a Xenograft Model of Ovarian Cancer

, , , , , , , , & show all
Pages 517-520 | Received 27 Jul 2016, Accepted 27 Sep 2016, Published online: 08 Nov 2016
 

ABSTRACT

Objectives: To investigate the tumor-suppressive properties of enzalutamide in androgen-driven ovarian cancer. Methods: Mice were implanted subcutaneously with OVCAR-3 cells and treated with dihydrotestosterone in combination with enzalutamide or vehicle control. Tumor volumes were measured twice weekly until day 56. Results: Dihydrotestosterone exposure led to a significant increase in tumor growth, while concomitant treatment with enzalutamide led to significant reductions in tumor volume compared to the androgen-exposed groups. Conclusions: We present the first evidence that the second-generation anti-androgen enzalutamide may possess efficacy in the treatment of ovarian cancer, paving the way for the future clinical trials.

Declaration of interest

Carol Aghajanian declares: consultation or advisory role, Astra Zeneca; travel, accommodations, and expenses, Astra Zeneca and Abb Vie. All other authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

This study was funded in part through the NIH/NCI support grant P30 CA008748.

Acknowledgments

The authors thank Esa R. Korpi for his advice and assistance with the manuscript.

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