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REVIEW

Hypoxia: A Double-Edged Sword in Cancer Therapy

, &
Pages 536-545 | Received 06 Jul 2016, Accepted 27 Sep 2016, Published online: 08 Nov 2016
 

ABSTRACT

Hypoxia is a common feature of malignant tumors. There is an interactive connection between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis. Therefore, tumor hypoxia has been considered as a validated target for treating cancer. This review focuses on the role of hypoxia on chemoresistance and radioresistance. In addition, we address several approaches targeting tumor hypoxia, known as hypoxia-targeted therapy.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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