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Serum Monitoring and Phenotype Identification of Stage I Non-Small Cell Lung Cancer Patients

James R. HockerDepartment of Biochemistry and Molecular biology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 853, Oklahoma City, OK, USA

Subrato J. DebDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA

Min LiDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA

Megan R. LernerDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA;Department of Veterans Affairs, Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, OK, USA

Stan A. LightfootDepartment of Veterans Affairs, Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, OK, USA

Aurelien A. QuilletDepartment of Biochemistry and Molecular biology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 853, Oklahoma City, OK, USA

R. Jane HanasDepartment of Biochemistry and Molecular biology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 853, Oklahoma City, OK, USA

Matthew ReinersmanDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA

Jess L. ThompsonDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA

Nicole T. VuAnalytical Research Laboratories BioPharma, 840 Research Parkway, Ste. 546, Oklahoma City, OK, USA

Thomas C. KupiecAnalytical Research Laboratories BioPharma, 840 Research Parkway, Ste. 546, Oklahoma City, OK, USA

Daniel J. BrackettDepartment of Veterans Affairs, Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, OK, USA

Marvin D. PeytonDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA

Stephen M. DubinettDavid Geffen School of Medicine, University of California, 10833 Le Conte Ave. CHS 37–131, Los Angeles, CA, USA

Harold M. BurkhartDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA

Russell G. PostierDepartment of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA

Jay S. HanasDepartment of Biochemistry and Molecular biology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 853, Oklahoma City, OK, USA;Department of Surgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, P.O. Box Williams Pavilion Room 2140. Oklahoma City, OK, USA;Department of Veterans Affairs, Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, OK, USACorrespondence[email protected]

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ABSTRACT

A stage I non-small cell lung cancer (NSCLC) serum profiling platform is presented which is highly efficient and accurate. Test sensitivity (0.95) for stage I NSCLC is the highest reported so far. Test metrics are reported for discriminating stage I adenocarcinoma vs squamous cell carcinoma subtypes. Blinded analysis identified 23 out of 24 stage I NSCLC and control serum samples. Group-discriminating mass peaks were targeted for tandem mass spectrometry peptide/protein identification, and yielded a lung cancer phenotype. Bioinformatic analysis revealed a novel lymphocyte adhesion pathway involved with early-stage lung cancer.

KEYWORDS:

Declaration of Interest statement

None of the co-authors have a conflict of interest pertaining to this manuscript. The co-authors have read the manuscript, contributed in an experimental and/or intellectual manner, and agree with its contents. Grant sponsors: Presbyterian Health Foundation, Oklahoma Tobacco Research Center, to J.S.H.; Grant P20RR016478 to A.M.Q., National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH).

Acknowledgments

This work was funded by the Oklahoma Center for the Advancement of Science and Technology, the Presbyterian Health Foundation, and the research funds of the University of Oklahoma Departments of Surgery and Biochemistry and Molecular Biology. We thank the Staff of the Department of Surgery for all their efforts on this study.

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Serum Monitoring and Phenotype Identification of Stage I Non-Small Cell Lung Cancer Patients

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Serum Monitoring and Phenotype Identification of Stage I Non-Small Cell Lung Cancer Patients

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