11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

Ciro FranzeseRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – ItalyCorrespondence[email protected]

Egesta LopciNuclear Medicine, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy

Lucia Di BrinaRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy

Giuseppe Roberto D'AgostinoRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy

Pierina NavarriaRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy

Pietro MancosuRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy

Stefano TomatisRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy

Arturo ChitiNuclear Medicine, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy;Humanitas University, Department of Biomedical Sciences, Via Manzoni 113 20089Rozzano (Milano) – Italy

Marta ScorsettiRadiotherapy and Radiosurgery, Humanitas Clinical and Research Center, Via Manzoni Rozzano (Milano) – Italy;Humanitas University, Department of Biomedical Sciences, Via Manzoni 113 20089Rozzano (Milano) – Italy

show all

ABSTRACT

Introduction: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.

Materials and methods: patients with 1 – 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.

Results: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).

Conclusion: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

KEYWORDS:

Declaration of interest statement

The authors report no declarations of interest

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

Information for

Open access

Opportunities

Help and information

11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

ABSTRACT

Declaration of interest statement

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature