http://orcid.org/0000-0002-1954-2892
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ABSTRACT
Wilms' tumor is one of the most common solid tumors of childhood; however, the genetic basis underlying the majority of cases remains largely unknown. HACE1 is a putative Wilms' tumor susceptibility gene. We investigated the association between five HACE1 gene polymorphisms and Wilms' tumor susceptibility in a Chinese population consisting of 145 patients and 531 controls. We found a significant association between HACE1 rs9404576 polymorphism and decreased Wilms' tumor risk. No significant association was detected for other polymorphisms in the overall analysis. Our results indicated that HACE1 rs9404576 polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population.
Declaration of interest
The authors report no conflicts of interest.
Funding
This study was supported by grants from Pearl River S&T Nova Program of Guangzhou (No: 201710010086), the Science and Technology Planning Project of Guangdong Province (No: 2016A020215009), State Clinical Key Specialty Construction Project (Pediatric Surgery) 2013 (No: GJLCZD1301), and Guangzhou Medical and Health Science and Technology projects in 2013 (No: 20131A011068).
