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Articles

MicroRNA-187 Inhibits Growth and Metastasis of Osteosarcoma by Downregulating S100A4

, , , &
Pages 1-9 | Received 23 Aug 2017, Accepted 06 Dec 2017, Published online: 05 Jan 2018
 

ABSTRACT

Abnormal expression and dysfunction of microRNAs are correlated with osteosarcoma (OS). This study demonstrated that the miR-187 level in OS tissues and cell lines was decreased. The proliferation and metastatic abilities of U-2OS cells were inhibited by miR-187 overexpression and promoted by miR-187 knockdown. Moreover, miR-187 also inhibited growth and metastasis of OS cells in vivo. Furthermore, we revealed that miR-187 could interact with S100A4 3′-UTR and inhibit S100A4 expression in OS cells. In summary, miR-187 inhibits growth and metastasis of OS cells by downregulating S100A4, which might be a potential biomarker and therapeutic target of OS.

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Funding

None to declare.

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