http://orcid.org/0000-0001-8083-7430
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Abstract
We examined if serum concentrations Interferon gamma-induced protein (IP-10) is a potential clinical biomarker for cancer-related-fatigue (CRF). Fatigue scores and IP-10 concentrations were measured from curatively treated fatigued cancer patients randomized to either cognitive behavioral therapy (CBT, n = 26) or waiting-list (WL, n = 13). No correlation was found between baseline IP-10 level and fatigue severity and no significant differences in IP-10 serum levels were observed between fatigued and matched non-fatigued patients (n = 22). Relative changes in IP-10 concentrations from baseline to six-month follow-up were not significantly different between the CBT and WL conditions. In this study, IP-10 showed low potential as clinical CRF biomarker.
Trial registration: This study is registered at ClinicalTrials.gov (NCT01096641).
Acknowledgments
We thank all patients who participated in this study. In special, we thank Jeanette Pots from the Department of Tumor Immunology, Radboud University Medical Centre, Nijmegen and Dr. Rene Lutter from the Department of Experimental Immunology, Academic Medical Center, Amsterdam for their assistance and prof. dr. Jan Willem Leer, Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen for referral of patients for this study.
Declaration of interest
The authors declared that they have no conflict of interest.
Additional information
Funding
Notes on contributors
Emil ter Veer
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
Hetty Prinsen
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
Mirjam A. G. Sprangers
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
Koos A.H. Zwinderman
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
Gijs Bleijenberg
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
Tineke C.T.M. van der Pouw Kraan
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
I. Jolanda M. de Vries
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
Eddy A. Wierenga
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.
Hanneke W.M. van Laarhoven
The original study was conducted by HP, GB, KZ, JdV and HvL. For the current sub-analysis, EtV, HP, HvL, JdV and EW were responsible for the data acquisition. EtV conducted the data analysis. EtV, HvL, EW, MS and TvdPK were involved in interpretation of the results and drafting the manuscript. All authors gave final approval of the current manuscript.