Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR

Tugba OrhanFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark; View further author information

Peter Böhm NielsenCentre for Immune Regulation and Reproductive Immunology, Department of Clinical Biochemistry, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark; View further author information

Thomas Vauvert F. HviidCentre for Immune Regulation and Reproductive Immunology, Department of Clinical Biochemistry, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark; View further author information

Andreas Weinberger RosenCenter for Surgical Science, Department of Surgery, Zealand University Hospital, University of Copenhagen, Koege, DenmarkView further author information

Ismail GögenürCenter for Surgical Science, Department of Surgery, Zealand University Hospital, University of Copenhagen, Koege, DenmarkCorrespondence[email protected]

http://orcid.org/0000-0002-3753-268X View further author information

Abstract

Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal cancer surgery compared to paired normal mucosa. No differences were observed in the expression of Per2, Bmal1, and Clock. In conclusion, abnormal expression levels of the clock genes Per1 and Per3 in CRC tissue may be related to tumourigenesis and may provide future diagnostic and prognostic information.

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The authors report no conflicts of interest.

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Funding

The study was supported by Spogaards Family Fund.

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Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR

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Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR

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