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Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review

Cléciton Braga TavaresPostgraduate Program of the Northeast Network of Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Brazil; Correspondence[email protected]

http://orcid.org/0000-0003-4816-0858

Francisca das Chagas Sheyla Almeida Gomes-BragaNursing Department, University Hospital of Piauí, Teresina, Brazil;

Emerson Brandao SousaNeurosurgery Department, Brasilia University, Brasília, Brazil;

José Nazareno Pearce de Oliveira BritoNeurology and Neurosurgery Discipline, State University of Piauí, Teresina, Brazil;

Mariella de Almeida MeloOncology Department, Hospital São Marcos, Teresina, Brazil;

Viriato CampeloPostgraduate Program in Health Sciences, Federal University of Piauí, Teresina, Brazil;

Fidelis Manes NetoOncology Department, Hospital São Marcos, Teresina, Brazil;

Ricardo Marques Lopes de AraújoNeurosurgery Department, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;

Iruena Moraes KesslerNeurosurgery Department, Brasilia University, Brasília, Brazil;

Leonardo de Moura Sousa JúniorNeurosurgery Department, São Paulo University, São Paulo, Brazil

Luís Carlos Carvalho FilhoOncology Department, Hospital São Marcos, Teresina, Brazil;

Yousef Qathaf AguiarOncology Department, Hospital São Marcos, Teresina, Brazil;

Pedro Vitor Lopes CostaPostgraduate Program in Health Sciences, Federal University of Piauí, Teresina, Brazil;

Benedito Borges da SilvaPostgraduate Program of the Northeast Network of Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Brazil;

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Abstract

This study aimed to determine the main single nucleotide polymorphisms (SNPs) that are associated with an increased or decreased risk of glioma development in healthy individuals. We conducted a systematic review of the articles published in English on the PUBMED database between January 2008 and December 2017. Our search resulted in a total of 743 articles; however, only 56 were included in this review. A total of 148 polymorphisms were found, which involved 64 different genes. The polymorphisms that were most associated with an increased risk of glioma development were polymorphic variants rs179782, rs13181, and rs3791679 of the genes XRCC1, ERCC2, and EFEMP1, respectively.

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Author contributions

CBT and BBS conceived the idea and wrote manuscript. FCSGB, EBS, JNPOB, MAM, VC, FMN, RMLA, IMK, LMS Jr, LCCF, and YQA critically reviewed the article and supervised the project.

Disclosure statement

The authors disclose that they have no competing interests.

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Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review

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Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review

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