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Cancer Investigation Volume 38, 2020 - Issue 8-9
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Coronavirus Spectrum Infections (COVID-19, MERS, SARS) in Cancer Patients: A Systematic Review of the Literature

Anne Kniselya Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA
,
Jenny Wua Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;c Duke University School of Medicine, Durham, North Carolina, USA
,
Samantha J. Kaplanc Duke University School of Medicine, Durham, North Carolina, USA
,
Zhen Ni Zhoua Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA
,
Alexander Melameda Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;d Herbert Irving Comprehensive Cancer Center, New York, New York, USA
,
Ana I. Tergasa Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;d Herbert Irving Comprehensive Cancer Center, New York, New York, USA
,
Caryn M. St. Claira Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;d Herbert Irving Comprehensive Cancer Center, New York, New York, USA
,
June Y. Houa Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;d Herbert Irving Comprehensive Cancer Center, New York, New York, USA
,
Fady Khoury-Colladoa Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;d Herbert Irving Comprehensive Cancer Center, New York, New York, USA
,
Yolanda Ya-chin Huanga Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA
,
Dawn L. Hershmana Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;d Herbert Irving Comprehensive Cancer Center, New York, New York, USA
&
Jason D. Wrighta Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA;b New York Presbyterian Hospital, New York, New York, USA;d Herbert Irving Comprehensive Cancer Center, New York, New York, USACorrespondence[email protected]
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Pages 436-444 | Received 17 May 2020, Accepted 10 Aug 2020, Published online: 05 Oct 2020
 
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Abstract

Background

Coronavirus 2019 (COVID-19) has spread rapidly around the world to become a global pandemic. There is limited data on the impact of COVID-19 among patients with cancer.

Methods

A systematic review was performed to determine outcomes of adult patients with cancer affected by coronavirus infections, specifically SARS, MERS, and COVID-19. Studies were independently screened by two reviewers and assessed for quality and bias. Outcomes measured included study characteristics, cancer type, phase of care at the time of diagnosis, and clinical presentation. Morbidity and mortality outcomes were analyzed to assess the severity of infection as compared to the general population.

Results

A total of 19 studies with 110 patients were included. Of these, 66.4% had COVID-19 infections, 32.7% MERS and only one patient with SARS. The majority of COVID-19 studies were based on studies in China. There was a 56.6% rate of a severe event, including ICU admission or requiring mechanical ventilation, with an overall 44.5% fatality rate.

Conclusions

Patients with cancer with coronavirus infections may be more susceptible to higher morbidity and mortality.

Disclosure statement

Dr. Wright served as a consultant for Clovis Oncology and received research funding from Merck.

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