Type 2 Diabetes Associated with Abnormal p53 Immunohistochemical Patterns in Colorectal Cancer

Abstract

Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated with p53-AP in overall patients, patients with microsatellite instability (MSI) stable/MSI-low phenotype or distal colorectal location. Furthermore, p53-AP was positively associated with lymph node metastasis and high TNM stage. Metformin treatment was negatively associated with p53-AP in T2DM patients. The results suggested T2DM might influence carcinogenesis, progression and prognosis via inducing TP53 mutation and abnormal p53 expression in CRC.

Keywords:

• p53
• TP53
• immunohistochemical pattern
• diabetes
• colorectal cancer

Author contributions

YZ designed the study and wrote the paper; MJ collected and analyzed the data; ZX and QG performed the research.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data used in the study are available from the corresponding author on reasonable request.

Additional information

Funding

Natural Science Foundation of Zhejiang Province of China (No. LY18H160044); Zhejiang Medical  Technology Plan Project  (No. 2019KY024).