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Articles

Efficacy and Safety of 4-Weekly Docetaxel for Castration-Resistant Prostate Cancer

, ORCID Icon, , , , , , , , , , & show all
Pages 251-256 | Received 29 Jul 2020, Accepted 30 Dec 2020, Published online: 14 Jan 2021
 

Abstract

We investigated the efficacy and safety profiles of 4-weekly docetaxel for castration-resistant prostate cancer. Patients treated with ≥2 courses of docetaxel chemotherapy (median, 70 mg/m2) between 2008 and 2018 were included. Among 125 Japanese men, 40 (32.0%) and 85 (68.0%) were treated with 3-weekly and 4-weekly regimens, respectively. In the 4-weekly regimen, the risks of progression, treatment failure, and any-cause mortality were comparable to those in the 3-weekly regimen. The incidences of severe adverse events were also similar between the 3-weekly and 4-weekly regimens. These data suggest that the 4-weekly regimen may be an acceptable option for selected patients.

Acknowledgments

The authors thank Nicole Okoh, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/) for editing a draft of this manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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