Normal Absolute Monocyte Count in Combination with Normal/High Absolute Lymphocyte Count at the Time of Relapse is Associated with Improved Survival in Patients with Early Relapsed Acute Myeloid Leukemia

Abstract

This study aimed to examine the prognostic significance of peripheral absolute monocyte count (AMC) in combination with absolute lymphocyte count (ALC) at the time of relapse in a cohort of 57 patients with early relapsed (first complete remission <12 months) acute myeloid leukemia (AML). Both univariate and multivariate Cox proportional hazard regression analyses revealed that normal AMC in combination with normal/high ALC (versus low/high AMC in combination with low ALC) was significantly associated with improved OS. We concluded that the combination of AMC and ALC could be used as a prognostic marker for survival outcomes in early relapsed AML.

Keywords:

• Acute myeloid leukemia
• early relapse
• absolute monocyte count
• absolute lymphocyte count
• survival

Disclosure statement

No potential competing interest was reported by the author(s).

Data availability statement

The data supporting this study are available at the correspondence author upon request.

Additional information

Funding

This work was supported by the Natural Science Foundation of Zhejiang Province under Grant numbers LY21H080006 and LQ19H080003, and the Public Welfare Science and Technology Project of Wenzhou under Grant number Y20160099.