Approaches for Head and Neck Cancer Research – Current Status and the Way Forward

Abstract

Head and neck cancers (HNCs) are seeing an increasing trend in their prevalence among both genders and are the seventh most common cancer type occurring at the global level. Studies addressing both the cancer cell physiology and individual differences in response to a specific treatment modality should be understood for arriving at effective treatment and management of the HNCs. In this article, we discuss the trends in HNC research and their various approaches starting from 2D in vitro models, which are the traditional experimental materials to recently established Cancer-Tissue Originated Spheroids (CTOS) distinctly contributing towards personalized or precision medicine.

Keywords:

• Cell lines
• 3D aggregates
• xenografts
• organoids
• precision medicine

Author contributions

Dr. MaddalyRavi conceptualized the theme and the overall manuscript design, preparation and revision; BarghaviV, Arokia Femina T and Archana K contributed for the manuscript preparation, revisions, tables and the figures; Divya Sowrirajan Iyengar contributed for the tables and for the revisions.

Disclosure statement

The authors have no relevant conflicts of interest to disclose.

Additional information

Funding

This manuscript is not a part of any funded project.