CD274 (PD-L1) Methylation is an Independent Predictor for Bladder Cancer Patients’ Survival

Abstract

This study was carried out to demonstrate the prognostic value of CD274 (PD-L1 promoter gene) methylation in bladder cancer patients. UCSC Xena database was searched for relevant information on PD-L1 (CD274) methylation and PD-L1 mRNA expression in bladder cancer. 407 bladder patients were included in our analyses. Multivariate analysis revealed that PD-L1 methylation was an independent predictor for OS (P = 0.037). Moreover, PD-L1 methylation might be a prognostic biomarker for immunotherapy response. However, PD-L1 methylation and PD-L1 mRNA expression was not statistically associated with chemotherapy response. In conclusion, PD-L1 methylation was an independent prognostic factor for bladder cancer patients.

Keywords:

• CD274
• PD-L1
• methylation
• survival
• immunotherapy

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Talent Research Fund Project of Hefei University (Grant No. 20RC07) and Information and Communication Engineering Project of Hefei University (Grant No. 20180xk03).