Magnetic Resonance Imaging Guided Prostate Biopsy in Patients with ≥ One Negative Systematic Transrectal Ultrasound-Guided Biopsy: A Systemic Review and Meta-Analysis

Abstract

The present study aimed to compare prostate cancer (PCa) and clinically significant PCa (csPCa) detection sensitivity between magnetic resonance imaging guided-biopsy (MRI-GB) and transrectal ultrasound-guided biopsy (TRUS-GB) in patients with ≥ 1 negative TRUS-GB, and to explore the additive value of TRUS-GB to MRI-GB. The meta-analysis of 18 studies demonstrated that MRI-GB had a similar sensitivity for PCa detection but a higher sensitivity for csPCa than TRUS-GB. In conclusion, there was limited value in combining TRUS-GB with MRI-GB compared with MRI-GB alone for csPCa detection in patients with one or more negative TRUS-GBs that were suspicious of having PCa.

Keywords:

• Prostate
• prostate cancer
• magnetic resonance imaging
• imaging guided biopsy
• negative biopsy

Author contributions

HL and GL searched literatures and screening all the articles. YZ and HZ extracted data from the included studies. YZ, GW and GL performed that data analysis. GL drafted the manuscript. All authors participated in idea design and manuscript checking.

Declaration of interest

The authors report no conflict of interest.

Data availability statement

All data generated or analysed during this study are included in this published article.