Tumoral Overexpression of Hepcidin is Associated with Poor Prognosis of Patients with Clear Cell Renal Cell Carcinoma

Abstract

This study aimed to investigate the prognostic value of tumoral HAMP expression in patients with clear cell renal cell carcinoma (ccRCC). In a TCGA dataset, we found that HAMP mRNA expression was increased in ccRCC tumors compared with normal controls. Tumoral HAMP mRNA expression was positively correlated with clinical stage, tumor grade, and TNM stages. Patients with high HAMP expression had poorer overall survival than those with low HAMP expression. Tumoral HAMP mRNA level independently predicted the survival of patients. HAMP protein expression was increased in real-world ccRCC tumors compared with those in paired, adjacent noncancerous tissue and was positively correlates with tumor grading. These results suggest HAMP as a potential prognostic factor for ccRCC patients.

Keywords:

• Hepcidin
• renal cell carcinoma
• disease severity
• prognosis

Declaration of Interest

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors acknowledge the financial grant by the Science and Technology Development Plan of Soochow in Jiangsu Province P.R.C. [grant numbers SKJYD2021015].