Single Nucleotide Polymorphisms Associated with Prostate Cancer Progression: A Systematic Review

Abstract

Background

New biomarkers of progression in patients with prostate cancer (PCa) are needed to improve their classification and clinical management. This systematic review investigated the relationship between single nucleotide polymorphisms (SNPs) and PCa progression.

Methods

A keyword search was performed in Pubmed, EMBASE, Scopus, Web of Science, and Cochrane for publications between 2007 and 2022. We included articles with adjusted and significant associations, a median follow-up greater than or equal to 24 months, patients taken to radical prostatectomy (RP) as a first therapeutic option, and results presented based on biochemical recurrence (BCR).

Results

In the 27 articles selected, 73 SNPs were identified in 39 genes, organized in seven functional groups. Of these, 50 and 23 SNPs were significantly associated with a higher and lower risk of PCa progression, respectively. Likewise, four haplotypes were found to have a significant association with PCa progression.

Conclusion

This article highlights the importance of SNPs as potential markers of PCa progression and their possible functional relationship with some genes relevant to its development and progression. However, most variants were identified only in cohorts from two countries; no additional studies reproduce these findings.

Keywords:

• Prostatic neoplasms
• polymorphism
• single nucleotide
• recurrence
• disease progression

Acknowledgments

The researchers thank Paula Daniela Morales for her contribution to this article.

Ethics and integrity statements

• Data availability statement: The authors confirm that data supporting the findings of this study are available in the article and its supplementary materials.

• Funding statement: No funding was received for the conduct of this study.

• Conflict of interest statement: The authors declare that they have no conflicts of interest.

• Ethical approval statement: Not applicable.

• Patient consent statement: Not applicable.

• Permission to reproduce material from other sources: Not applicable.

• Clinical trial registration: Not applicable.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.