Vacuum Contact Drying Kinetics: An Experimental Parametric Study

Abstract

Vacuum contact drying kinetics of a model system consisting of nonporous glass beads and water has been experimentally measured on a laboratory scale. A methodology for determination of drying curves from experimental data in a statistically robust way has been developed. The effects of jacket temperature, head-space pressure, particle bed depth, vessel diameter, and particle size on drying rate during constant and falling rate periods have been studied. It was found that in the range of parameters investigated, drying rate does not depend on the means of realization of the driving force (by temperature or pressure); drying rate in the constant-rate period decreases with increasing bed depth while the overall heat-transfer rate increases due to increased surface area. A very strong dependence of drying rate and regime on particle size was observed; the constant-rate period disappeared for small particles.

Keywords:

• Vacuum drying
• Contact drying
• Driving force
• Heat transfer
• Vessel geometry
• Scale-up
• Particle size

ACKNOWLEDGEMENT

Funding for this research project has been provided by GlaxoSmithKline, Ltd.