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Drying Technology
An International Journal
Volume 24, 2006 - Issue 7
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Original Articles

Freeze-Drying of Pharmaceutical Products: Research and Development Needs

H. Sadikoglu Department of Chemical Engineering, Gebze Institute of Technology, Gebze, Kocaeli, TurkeyCorrespondence[email protected]
,
M. Ozdemir Department of Chemical Engineering, Gebze Institute of Technology, Gebze, Kocaeli, Turkey
&
M. Seker Department of Chemical Engineering, Gebze Institute of Technology, Gebze, Kocaeli, Turkey
Pages 849-861 | Published online: 06 Feb 2007
 
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Abstract

Significance of pharmaceutical formulation (choosing of correct excipients in optimal quantities), effects of glass transition temperature, importance of theoretical modeling of the process, benefits of optimal control, and the advantages of remote monitoring of the process are presented. Experimental and theoretical research and development needs for the freeze-drying of pharmaceutical products are proposed and discussed.

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