Encapsulation of Proteins by Spray Drying and Crystal Transformation Method

Abstract

Spray drying is commonly used as a dehydration technique in the pharmaceutical industry for making powdery products directly from liquid. It is also an attractive alternative for obtaining solid pharmaceutical molecules that are traditionally produced by freeze drying. Spray drying is often regarded as a harsh drying method, due to the high temperature of the drying gas. Therefore, some excipients were added to improve the stability in manufacturing process and storage. Emphasis was placed on the encapsulation of proteins by spray drying and crystal transformation method.

Keywords:

• Crystal transformation
• Encapsulation
• Protein
• Spray drying