DRYING KINETICS OF A MULTICOMPONENT MIXTURE OF ORGANIC SOLVENTS

ABSTRACT

Drying kinetics of volatile organic solvents have been examined during the drying process of a pharmaceutical coating containing a multicomponent mixture of ethyl acetate, n-heptane, propanol-2, and toluene. A complete set of experiments was performed in two drying apparatuses, a laboratory air-dryer and an oven dryer, for a wide range of drying temperature, air velocity, initial coating thickness and drying time. An empirical kinetic model is used to predict the concentration of each organic solvent in the mixture during the drying process. The results show that both drying conditions and sample characteristics affect significantly the drying rate of solvents.

KeyWords and Phrases:

• Empirical kinetic model
• drying
• pharmaceuticals
• multicomponent organic mixture