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Journal of Biomolecular Structure and Dynamics Volume 4, 1986 - Issue 2
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Original Articles

A New Bithiazole Derivative with Intercalative Properties

Raymond Houssin Institut de Chimie Pharmaceutique, Universit[etilde] de Lille II, rue Laguesse, 59045, Lille, France
,
Nicole Helbecque D[etilde]partment de Biochimie, Facult[etilde] de M[etilde]decine, Place de Verdun, 59045, Lille, France
,
Jean-Luc Bernier INSERM U16, Place de Verdun, 59045, Lille, France
&
Jean-Pierre H[etilde]nichart INSERM U16, Place de Verdun, 59045, Lille, France
Pages 219-229 | Received 28 Apr 1986, Published online: 15 May 2012
 
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Abstract

In the course of studies related to new molecules with intercalative properties, we have been led to design and synthesize a bithiazole derivative, namely the 2-phenyl-6- [2′-(4′-(ethoxy-carbony1)thiazoly1)] thiazolo[3,2-b] [1,2,4]triazole (PETT). Its interaction with calf thymus DNA was studied using thermal denaturation and viscometry. Our results set in evidence that PETT acts as an intercalator, giving Δ Tm, elongation and unwinding of DNA comparable to the values obtained for daunorubicin. The discrepancy between the data presented herein and those precedently obtained for bleomycin and bleomycin models provide evidence that these bithiazole derivatives interact differently with DNA.

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