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Journal of Biomolecular Structure and Dynamics Volume 14, 1997 - Issue 5
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Original Articles

Sequential Arrangement, Not Transcriptional Activity, Determines Conformational Stability of Nucleosomes

Sergey Belikov W. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 117984, Moscow, Russia; Department of Cell and Molecular Biology, The Medical Nobel Institute, Karolinska Institutet, S-171 77, Stockholm, Sweden
,
Dmitrij Papatsenko
,
Olga Preobrazhenskaya
,
Vladimir Sushkov
&
Vadim Karpov
Pages 651-655 | Received 20 Jan 1997, Published online: 21 May 2012
 
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Abstract

Gel electrophoresis in urea gradient was applied to study the unfolding effect of increasing concentrations of urea on the nucleosome structure. We showed that conformational stability of nucleosomes is determined by nucleotide sequence but not by transcriptional activity of DNA in chromatin.

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