Advanced search
Publication Cover
Journal of Biomolecular Structure and Dynamics Volume 16, 1998 - Issue 1
Journal homepage
21
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

23Na NMR Study of the Interaction Between DNA and the Platinum (II) Compounds: Cis-DDP, Trans-DDP and TDP

Georges Mallet Laboratoire de Biophysique—;GRECFO, Université de Nice-Sophia Antipolis, Pare Valrose, 06108, Nice Cedex 2, France
,
Seddik Ansiss Laboratoire de Biophysique—;GRECFO, Université de Nice-Sophia Antipolis, Pare Valrose, 06108, Nice Cedex 2, France
&
Dan Vasilescu Laboratoire de Biophysique—;GRECFO, Université de Nice-Sophia Antipolis, Pare Valrose, 06108, Nice Cedex 2, France
Pages 21-33 | Received 09 Feb 1998, Published online: 21 May 2012
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

The interaction of calf thymus DNA with cis-DDP, trans-DDP and TDP was studied by 23Na NMR in aqueous solutions at pH = 7.0, with Pt(II) compounds/DNA(P) (P=Phosphate) molar ratios r increasing from 0 till to IP.

23Na NMR results are interpreted on one hand, with the help of a “ two states model with Rf and RB relaxation rates, and, on the other hand, using the “entropy of fluctuations” concept developed by Lenk. We have established that, for the studied platinum compounds, the preference to interact with DNA phosphate sites—interpreted as a perturbation of the counterions environment- is in a decreasing order: TDP ≫ cis-DDP > trans-DDP. These results are discussed with regard to the interaction of DNA with the hard bication Mg++ and the soft bication Cu++.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

23Na NMR investigation of the interaction between DNA and divalent metallic cations
Source: Springer Science and Business Media LLC
New chemistry of an old molecule: cis-[Pt(NH3)2Cl2]
Source: American Association for the Advancement of Science (AAAS)
The mechanism of action of antitumor platinum compounds.
Source: Elsevier
Drugs five years later. Cisplatin.
Source: American College of Physicians
Sodium‐23 Nuclear Magnetic Resonance Spectroscopy
Source: Wiley
Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation
Source: American Chemical Society (ACS)
Demonstration of the interaction of cysteamine with DNA using 23Na nmr technique
Source: Wiley
An analysis of non-Lorentzian sodium-23 line shapes in two model systems
Source: American Chemical Society (ACS)
Limiting Laws and Counterion Condensation in Polyelectrolyte Solutions I. Colligative Properties
Source: AIP Publishing
Modifications of the DNA secondary structure upon platinum binding: a proposed model
Source: Elsevier BV
Time-evolution of the entropy of fluctuations in some biological systems as investigated by NMR
Source: Elsevier BV
Platinum Complexes for the Treatment of Cancer
Source: Informa UK Limited
DNA-PLATINE INTERACTION
Source: Wiley
Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II).
Source: American Chemical Society (ACS)
Ion Binding in Biological Systems as Studied by NMR Spectroscopy
Source: John Wiley & Sons, Inc.
Ultraviolet difference spectral study of the interaction of DNA with platinum complexes
Source: Elsevier BV
Dependence of the melting temperature of DNA on salt concentration
Source: Wiley
Electronic structure of platinum(II) antitumor complexes and their interactions with nucleic acid bases. I
Source: Elsevier BV
Platinum coordination complexes in cancer chemotherapy
Source: Springer Science and Business Media LLC
Absolute Electronegativity and Hardness: Application to Inorganic Chemistry
Source: American Chemical Society (ACS)
Proceedings of the 5th UNESCO International Conference
Source: Birkhäuser Basel
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
Source: Springer Science and Business Media LLC
Synthesis, characterization, in vitro antitumor activity, DNA-binding properties and electronic structure (DFT) of the new complex cis-(Cl,Cl)[RuIICl2(NO+)(terpy)]Cl.
Source: Royal Society of Chemistry (RSC)
Conformational analysis of the adduct cis-[Pt(NH3)2 d(GpG)]+ in aqueous solution. A high field (500-300 MHz) nuclear magnetic resonance investigation.
Source: Oxford University Press (OUP)
Biological Processing of DNA Modified by Platinum Compounds
Source: John Wiley & Sons, Inc.
Heavy metal nucleotide interactions. 12. Competitive reactions in systems of four nucleotides with cis- or trans-diammineplatinum(II). Raman difference spectrophotometry of the relative nucleophilicity of guanosine, cytidine, adenosine, and uridine monophosphates and analogous DNA bases
Source: American Chemical Society (ACS)
The antitumor drug cis-dichlorodiammineplatinum forms an intrastrand d(GpG) crosslink upon reaction with [d(ApGpGpCpCpT)]2
Source: American Chemical Society (ACS)

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.