Homology modeling: an important tool for the drug discovery

Abstract

In the last decades, homology modeling has become a popular tool to access theoretical three-dimensional (3D) structures of molecular targets. So far several 3D models of proteins have been built by this technique and used in a great diversity of structural biology studies. But are those models consistent enough with experimental structures to make this technique an effective and reliable tool for drug discovery? Here we present, briefly, the fundamentals and current state-of-the-art of the homology modeling techniques used to build 3D structures of molecular targets, which experimental structures are not available in databases, and list some of the more important works, using this technique, available in literature today. In many cases those studies have afforded successful models for the drug design of more selective agonists/antagonists to the molecular targets in focus and guided promising experimental works, proving that, when the appropriate templates are available, useful models can be built using some of the several software available today for this purpose. Limitations of the experimental techniques used to solve 3D structures allied to constant improvements in the homology modeling software will maintain the need for theoretical models, establishing the homology modeling as a fundamental tool for the drug discovery.

Keywords:

• drug discovery
• homology modeling
• theoretical models
• structural biology

Additional information

Funding

Funding. The author wish to thank the Military Institute of Engineering for the infrastructure, the Brazilian financial agencies CNPq (Grant no. 304557/2012-9), FAPERJ (Grant no. E-26/102.993/2012), and CAPES (Grant no. PD 1782/2008), for financial support.