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Abstract
The new synthesized Cu(II) chelates of amino acids Schiff bases were studied as a potential radioprotectors. Male albino rats of Wistar strain were exposed to X-ray whole-body irradiation at 4.8 Gy. This dose caused 30% mortality of the animals (LD30). The survival of animals exposed to radiation after preliminary administration of 10 mg/kg Cu(II)(Nicotinyl-l-Tyrosinate)2 or Cu(II)(Nicotinyl-l-Tryptophanate)2 prior to irradiation was registered about 80 and 100% correspondingly. Using spectrophotometric melting and agarose gel electrophoresis methods, the differences between the DNA isolated from irradiated rats and rats pretreated with Cu(II) chelates were studied. The fragments of DNA with different breaks were revealed in DNA samples isolated from irradiated animals. While, the repair of the DNA structure was observed for animals pretreated with the Cu(II) chelates. The results suggested that pretreatment of the irradiated rats with Cu(II)(Nicotinyl-l-Tyrosinate)2 and Cu(II)(Nicotinyl-l-Tryptophanate)2 compounds improves the liver DNA characteristics.
Acknowledgment
The authors are grateful for support. We thank Dr V. Matosyan, Dr V. Tonoyan, and Dr K. Babayan for synthesis of Cu(II)(Nicotinyl-l-Tyrosinate)2 and Cu(II)(Nicotinyl-l-Tryptophanate)2.
Disclosure statement
No potential conflict of interest was reported by the authors.