A double-edged sword: supramolecular complexes of triazavirine display multicenter binding effects which influence aggregate formation

Yana A. ZabrodskayaMolecular Biology of Viruses Department, Smorodintsev Research Institute of Influenza, Ministry of Healthcare of the Russian Federation, St. Petersburg, Russia; ;Molecular and Radiation Biophysics Department, Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Center “Kurchatov Institute”, Gatchina, Russia; Correspondence[email protected] [email protected]

http://orcid.org/0000-0003-2012-9461

Alexey V. ShvetsovMolecular and Radiation Biophysics Department, Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Center “Kurchatov Institute”, Gatchina, Russia; ;Supercomputer Center, Peter the Great Saint-Petersburg State Polytechnic University, St. Petersburg, Russia;

http://orcid.org/0000-0003-1140-5751

Vladimir B. TsvetkovMolecular Biology of Viruses Department, Smorodintsev Research Institute of Influenza, Ministry of Healthcare of the Russian Federation, St. Petersburg, Russia; ;Biophysics Department, Research and Clinical Center for Physical Chemical Medicine, Moscow, Russia; ;Polyelectrolytes and Biomedical Polymers Laboratory, A.V. Topchiev Institute of Petrochemical Synthesis, RAS Moscow, Russia;

http://orcid.org/0000-0003-0494-3332

Vladimir V. EgorovMolecular Biology of Viruses Department, Smorodintsev Research Institute of Influenza, Ministry of Healthcare of the Russian Federation, St. Petersburg, Russia; ;Molecular and Radiation Biophysics Department, Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Center “Kurchatov Institute”, Gatchina, Russia; ;Molecular Genetics Department, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, St. Petersburg, Russia

http://orcid.org/0000-0002-3670-8962

Abstract

Communicated by Ramaswamy H. Sarma

Acknowledgements

The results of the work were obtained using computational resources of Department of Information and Computational Technologies of the St. Petersburg State Polytechnic University (http://www.spbstu.ru). We thank Mr. Edward Ramsay for help in writing the manuscript and Dr. D.V. Lebedev (DMRB PNPI NRC KI) for fruitful discussion of the experiments.

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No potential conflict of interest was reported by the authors.

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A double-edged sword: supramolecular complexes of triazavirine display multicenter binding effects which influence aggregate formation

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A double-edged sword: supramolecular complexes of triazavirine display multicenter binding effects which influence aggregate formation

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