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Acknowledgements
We thank the anonymous reviewers for their helpful comments. We thank Igor N. Berezovsky for the closed loops data from DHcL server obtained on request. We thank Mathilde Carpentier for valuable discussions and advices. We thank Pierre Poulain for providing the code to compute eigenvalues of the principal axes (available at https://github.com/pierrepo/principal_axes). The RPBS platform and Pierre Tuffery are acknowledged for maintaining the method online.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the Emergence-Sorbonne Université research program and the Centre National de la Recherche Scientifique (CNRS).