Discovery of novel and highly selective PI3Kδ inhibitors based on the p110δ crystal structure

Wen-Qing JiaTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China; View further author information

Ya-Ya LiuTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China; View further author information

Xiao-Yan FengTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China; View further author information

Wei-Ren XuTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, ChinaView further author information

Xian-Chao ChengTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China; Correspondence[email protected]
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Abstract

Communicated by Ramaswamy H. Sarma

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No potential conflict of interest was reported by the authors.

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Funding

This work was supported by the [Natural Science Foundation of Tianjin] under Grant [number 18JCYBJC28800]; [Opening Project of Shanghai Key Laboratory of New Drug Design] under Grant [number SKLNDD-KF-201803]; [National Natural Science Foundation of China] under Grant [number 21202120].

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Discovery of novel and highly selective PI3Kδ inhibitors based on the p110δ crystal structure

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Discovery of novel and highly selective PI3Kδ inhibitors based on the p110δ crystal structure

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