On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity

Fatma Elrashdya Department of Endemic Medicine and Hepatogastroenterology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt

Abdullah A. Aljaddawib Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Elrashdy M. Redwanb Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence[email protected] [email protected]

https://orcid.org/0000-0001-8246-0075

Vladimir N. Uverskyb Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia;c Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA;d Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”, Pushchino, RussiaCorrespondence[email protected] [email protected]

https://orcid.org/0000-0002-4037-5857

Abstract

We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this “Trojan horse” strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7–14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this “silence” time period and then started to re-spread again.

Communicated by Ramaswamy H. Sarma

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On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity

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On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity

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