Imidazopyridine, a promising scaffold with potential medicinal applications and structural activity relationship (SAR): recent advances

Abstract

Imidazopyridine scaffold has gained tremendous importance over the past few decades. Imidazopyridines have been expeditiously used for the rationale design and development of novel synthetic analogs for various therapeutic disorders. A wide variety of imidazopyridine derivatives have been developed as potential anti-cancer, anti-diabetic, anti-tubercular, anti-microbial, anti-viral, anti-inflammatory, central nervous system (CNS) agents besides other chemotherapeutic agents. Imidazopyridine heterocyclic system acts as a key pharmacophore motif for the identification and optimization of lead structures to increase medicinal chemistry toolbox. The present review highlights the medicinal significances of imidazopyridines for their rationale development as lead molecules with improved therapeutic efficacies. This review further emphasis on the structure–activity relationships (SARs) of the various designed imidazopyridines to establish a relationship between the key structural features versus the biological activities.

Communicated by Ramaswamy H. Sarma

Keywords:

• Biological activity
• imidazopyridine
• leads
• molecular modeling
• structural activity relationship

Acknowledgments

The authors are thankful to Prof. Prasad V. Bharatam, Professor Medicinal Chemistry at NIPER Mohali, for constant support and encouragement.

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.