The CLOCK 3111T/C single nucleotide polymorphism and daytime fluctuations of gastric motility in healthy young women: A preliminary study

ABSTRACT

The 3111T/C single nucleotide polymorphism (SNP) of Circadian Locomotor Output Cycles Kaput (CLOCK) gene reportedly affects gastric motility before breakfast. It is of interest to know whether this SNP can affect the motility during the daytime. We investigated the association between the CLOCK 3111T/C SNP and several gastric motility parameters during the time period from 8:00 to 20:00 in 34 young women with scheduled meals. There were similar daytime fluctuations in gastric motility before and after the meals between the major (T/T) and minor (T/C) allele carriers. The CLOCK SNP may affect daytime gastric motility less than food stimulation.

KEYWORDS:

• Clock
• daytime fluctuations
• electrogastrography
• human
• polymorphism

Acknowledgments

We are grateful to all of the subjects of the study for their cooperation.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Funding

This work was supported by Grant-in-Aid for Scientific Research (B), Grant Number [JPI5H0Z90I] of Japan Society for the Promotion of Science (JSPS).

Additional information

Funding

This work was supported by Grant-in-Aid for Scientific Research (B), Grant Number [JPI5H0Z90I] of Japan Society for the Promotion of Science (JSPS).