Discussion on “A Hybrid Selection and Testing Procedure with Curtailment for Comparative Clinical Trials” by Elena M. Buzaianu and Pinyuen Chen

Abstract

This discussion contains some comments on the paper by Professors Buzaianu and Chen. These concern the form of the two-stage design used and possible future work, such as the consideration of alternative stopping rules, the incorporation of response-adaptive sampling, and the problem of estimation following the design.

Keywords:

• Conditionally unbiased estimator
• Expected successes lost
• Response-adaptive sampling
• Stopping rule

Subject Classification:

• 62F03
• 62F07
• 62P10

Notes

Recommended by Nitis Mukhopadhyay