Effect of exercise intervention on lung function in asthmatic adults: a network meta-analysis

Abstract

Objective

Exercise has traditionally been viewed as a contraindication for individuals with asthma, as it was believed to trigger or worsen acute asthma attacks. However, with scientific and appropriate exercise training, it has been proven that respiratory function and exercise capacity can be effectively improved and enhanced in asthma patients. This study aimed to compare the effects of different types of exercise on pulmonary function in adult patients with asthma using Network Meta-analysis.

Methods

We conducted a comprehensive search of electronic databases such as PubMed, Cochrane Library, Web of Science, CNKI for randomized controlled trials (RCTs) that investigated the effects of exercise on lung function in adult patients with asthma from inception to February 2023. Information including on first author, publication time, total sample size, intervention period, interventions, and outcome indicators were collected, and relevant statistical analyses were performed using Stata 17.0 software and Revman 5.4.

Results

A total of 28 randomized controlled trials with 2,155 patients with asthma were finally included. The results of Network Meta-analysis showed that compared with control group, breathing training (BT)、aerobic training (AT)、relaxation training (RT)、yoga training (YG) and breathing combined with aerobic training (BT + AT) improved Forced Expiratory Volume in the first second (FEV1) levels; AT、BT、YG and BT + AT improved the level of Forced Vital Capacity (FVC); BT、AT、RT、YG and BT + AT improved Peak Expiratory Flow (PEF); BT、AT、and YG improved Forced Expiratory Volume in the first second/Forced Vital Capacity (FEV1/FVC).The results of SUCRA probability ranking showed that RT had the most significant effect on improving the FEV1[SMD = 1.13,95%CI(0.83,1.43), p<0.001] levels, BT + AT had the most significant effect on improving the FVC[SMD = 0.71,95%CI(0.47,0.95), p<0.001] level; YG had the most significant effect on improving the PEF[SMD = 0.79,95%CI(0.55,1.02), p<0.001] level.

Conclusions

BT + AT and YG may be more advantageous in improving lung function in adult asthmatics.

Keywords:

• Exercise
• bronchial asthma
• lung function
• network meta-analysis

Authors' contributions

StX and SjF searched the literatures, analyzed data and wrote manuscript. StX and DZ supported writing manuscript. All authors have read and agreed to the published version of the manuscript.

Disclosure statement

The authors declare no conflict of interest.

Author disclaimer'

The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Data availability statement

All data generated or analysed during this study are included in this published article.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.